SayPad 

SayPad, the freeware talking text editor can read you a good book or help you write one, using SAPI 5.1 Text To Speech (included). It can convert Text to MP3 for a whole book in one run, splitting off chapters into well named MP3 files.
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4BlindMice 

Real Time Screen Reading talking mouse works with existing reader to provide GUI. Run your hands over the screen and get the big picture. Drive your mouse full speed across the screen, knowing in real time where you are and what you're flying over.
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UltraMouse 

UltraMouse is a very cool utility to help you make better use of your mouse by popping up a button menu and othermove-based trigger, you can assign a function to every trigger, the functions includes simulate keystokes, launch a file and more.
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